Integrative Assessment of Chlorine-Induced Acute Lung Injury in Mice
نویسندگان
چکیده
منابع مشابه
Chlorine gas induced acute lung injury in isolated rabbit lung.
This study was designed to investigate the pathogenesis of chlorine gas (Cl2) induced acute lung injury and oedema. Isolated blood-perfused rabbit lungs were ventilated either with air (n=7) or air plus 500 parts per million (ppm) of Cl2 (n=7) for 10 min. Capillary pressure, measured by analysing the pressure/time transients of pulmonary arterial, venous and double (both arterial and venous) oc...
متن کاملChlorine Gas Exposure Manifesting Acute Lung Injury
Chlorine is a yellowish-green gas with a pungent, irritating odor. It is intermediate water-soluble and can cause acute damage to both upper and lower respiratory tracts. Its toxicity is thought to be mediated by the generation of hydrogen chloride upon contact with moist mucous membrane and by the formation of free radicals at the cellular level. Toxic exposures to chlorine were first reported...
متن کاملTime course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats
Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI). Materials ...
متن کاملDeviations from Haber's Law for multiple measures of acute lung injury in chlorine-exposed mice.
Chlorine gas is considered a chemical threat agent that can cause acute lung injury. Studies in the early 20th century on war gases led Haber to postulate that the dose of an inhaled chemical expressed as the product of gas concentration and exposure time leads to a constant toxicological effect (Haber's Law). In the present work, mice were exposed to a constant dose of chlorine (100 ppm-h) del...
متن کاملMechanisms and modification of chlorine-induced lung injury in animals.
Chlorine (Cl(2)) is a reactive oxidant gas used extensively in industrial processes. Exposure of both humans and animals to high concentrations of Cl(2) results in acute lung injury, which may resolve spontaneously or progress to acute respiratory failure. Injury to airway and alveolar epithelium may result from chemical reactions of Cl(2), from HOCl (the hydrolysis product of Cl(2)), and/or fr...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2012
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2012-0026oc